CYP3A4 is a member of the cytochrome P450 superfamily of enzymes.The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of steroids (including cholesterol), and other lipids. [5]The CYP3A4 protein localizes to the endoplasmic reticulum, and its expression is induced by glucocorticoids and some pharmacological agents. [5]

cyp3a4 是细胞色素p450氧化酶家族成员之一。这个家族中的若干其它成员也涉及到药物的代谢，但cyp3a4是最常见和最多面的一个。与该家族所有成员类似，它（ cyp3a4 ）是一种 血红素蛋白 ——一种含有附带了一个铁原子的 亚铁血红素 (英语 ： heme)基团的蛋白质。对 ...

CYP3A4是细胞色素P450超家族酶类中的一员。细胞色素P450蛋白质是单氧酶类，可以催化涉及药物代谢以及胆固醇、类固醇和其它脂类成分的合成的众多反应。. CYP3A4蛋白位于细胞的内质网（英語： endoplasmic reticulum ）中，其表达受糖皮质激素（英語： glucocorticoid ）和一些药物 …

Cytochromes P450 3A4 and 3A5 are involved in the metabolism of many drugs, and there are many genetic variants of these two enzymes due to, for example, nucleotide mutations. Currently, commonly used methods for detecting polymorphisms in these two genes include DNA sequencing analysis, Polymerase chain reaction-restriction fragment length ...

2024年12月24日 · CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) is a Protein Coding gene. Diseases associated with CYP3A4 include Vitamin D-Dependent Rickets, Type 3 and Drug Metabolism, Poor, Cyp2c19-Related.Among its related pathways are Clomipramine Pathway, Pharmacokinetics and Metapathway biotransformation Phase I and II.Gene Ontology (GO) annotations related to this gene include enzyme binding ...

2017年9月11日 · cyp3a4是细胞色素p450家族中最为重要的药物代谢酶,其在外源性物质和内源性物质的代谢中起着极其重要的作用。 本文通过查阅国内外相关文献,对CYP3A4的基本结构、活性部位、作用机制、基因表型、探针底物和药物代谢等方面的研究进展作一综述,从而阐明CYP3A4与 ...

Cytochrome P450 3A4 (CYP3A4) is the most important drug-metabolizing enzyme in humans and has been associated with harmful drug interactions. The activity of CYP3A4 is known to be modulated by several compounds and by the electron transfer partner, cytochrome P450 reductase (CPR). The underlying mechanism of these effects, however, is poorly ...

Cytochrome P450 3A4 is an enzyme involved in the metabolism of taxanes, particularly in the liver, and plays a role in chemotherapy resistance in certain solid tumors like ovarian cancer cells. AI generated definition based on: Overcoming Drug Resistance in Gynecologic Cancers, 2021.

Zhou SF. 2008. Potential strategies for minimizing mechanism-based inhibition of cytochrome P450 3A4. Current Pharmaceutical Design 14: 990–1000. du Souich P, Fradette C. 2011. The effect and clinical consequences of hypoxia on cytochrome P450, membrane carrier proteins activity and expression.

2013年3月7日 · Cytochromes P450 (CYPs) represent a diverse group of heme-thiolate proteins found in almost all organisms. CYPs share a common protein fold but differ in substrate selectivity and catalyze a wide variety of monooxygenation reactions via activation of molecular oxygen. Among 57 human P450s, the 3A4 i …