A neutralizing antibody is defined as an antibody that is naturally produced by the immune system in response to infection, playing a crucial role in defending against viral infections by binding to the virus in a way that blocks infection.

2021年3月11日 · Neutralizing antibodies are naturally occurring antibodies that play an important role in the immune system. They work alongside binding antibodies that signal the presence of a pathogen...

2024年11月23日 · A neutralizing antibody defends a cell from an antigen or infectious body by inhibiting or neutralizing any effect it has biologically. The antibody response is crucial for preventing many viral infections and may also contribute to the resolution of an infection.

Neutralizing antibodies are antibodies against viral surface antigens, which can bind to the free virus in the body to prevent it from being absorbed and invade cells. From: International Immunopharmacology, 2021

Neutralizing antibodies (NAbs) are central players in the humoral immunity that defends the body from SARS-CoV-2 infection by blocking viral entry into host cells and neutralizing their biological effects.

2024年7月6日 · Neutralizing antibodies are integral to the body’s defense strategy, orchestrating a multifaceted response against pathogens. Once a pathogen invades, the immune system mounts a rapid response, deploying various cells and molecules to identify and neutralize the threat.

Collectively, antibodies that can directly neutralize the virus without the aid of other immune cells or immune factors are referred to as neutralizing antibodies. Unsurprisingly, following vaccination, the generation of neutralizing antibodies is one of the best predictors of protection against future infections [ 61 ].

A neutralizing antibody (NAb) is an antibody that protects the host cell from pathogens by neutralizing or inhibiting its biological effect. It blocks interactions of the viral envelope with the host cell receptor or inhibits the release of the viral genome.

Neutralizing antibody (NAb) evaluations are useful for the determination of individual or herd immunity against SARS-CoV-2, vaccine efficacy, and humoral protective response longevity, as well as supporting donor selection criteria for convalescent plasma therapy.

With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies.