2024年3月5日 · Woan KV, Kim H, Bjordahl R, Davis ZB, Gaidarova S, Goulding J, et al. Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy. Cell Stem Cell. 2021;28 ...

2020年9月15日 · The field of natural killer (NK) cell-based immunotherapy of cancer has reached an exciting juncture. Although these therapies have not yet achieved the same degree of clinical success as adoptive ...

2020年1月6日 · Beyond immunotherapy, recent data suggest that molecularly targeted agents that induce senescence in tumour cells can elicit NK cell-mediated antitumour activity 216, further supporting the notion ...

The concept of adoptive NK cell cancer immunotherapy was proven a decade ago from pioneering clinical studies against hematological malignancies. The difficulty to obtain large quantity of NK cells, to expand to clinical scale ex vivo, and to sustain in vivo survival and activity of infused NK cells has encumbered the progress. ...

2021年1月6日 · There are great numbers of clinical trials on NK cell immunotherapy to treat solid tumors. For example, there is an ongoing phase 2 clinical trial to evaluate the safety and efficacy of human HLA-haploidentical hematopoietic cell transplantation (HCT) followed by an early, post-transplant infusion of donor NK cells (NCT02100891). ...

2022年5月23日 · As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of innate immune regulatory cell. NK cells can rapidly kill multiple adjacent cancer cells through non-MHC-restrictive effects. Although tumors may develop multiple resistance mechanisms to endogenous NK cell attack, in vitro activation, expansion, and ...

A type of immune cell with significant potential for use in immunotherapy is the natural killer (NK) cell. The number of NK cells in the cancer tissues has been shown to be lower than normal, and this contributes to the growth of cancer cells. Besides, the immune function of the NK cells is compromised, thus interfering with anticancer immunity.

Another important limitation of NK cell immunotherapy is its low efficacy against solid tumors. This may due to the low ability of NK cells to traffic through the solid tumor tissues. The tumor microenvironment is another obstacle to the adoptive therapy of NK cells since tumor microenvironment interferes with NK cell activation by secreting ...

2024年1月1日 · In this article, we will review the recent advances in NK cell-based tumor immunotherapy, including the mechanism of NK cell activation and inhibition in tumor, rational design, fabrication and application of bionanomaterials for enhancing efficacy of NK cell-based tumor immunotherapy, and the new trends and clinical challenges (Fig. 1).

Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers associated with oncogenic transformation. This property, which is unique among immune cells, and their capacity to enhance antibody and T cell responses support a role for NK cells as anticancer agents. …