2023年3月17日 · Kidney fibrosis is identified by tubule atrophy, interstitial chronic inflammation and fibrogenesis, glomerulosclerosis, and vascular rarefaction.

In the obstructed kidney, paricalcitol prevented the renal fibrosis and suppressed the production of matrix proteins such as collagens I, III, and TGF-ß1 [158,168], and in a CKD induced by puromycin, calcitriol prevented the interstitial fibrosis .

Interstitial fibrosis is a common feature of chronic kidney disease, regardless of the etiology of the primary renal syndrome. Moreover, interstitial fibrosis is the strongest morphologic predictor of clinical outcome and is most tightly linked to progression of disease, even though the primary dise …

2023年10月5日 · Kidney interstitial fibrosis damages the interstitial tissue in the kidneys, causing a buildup of collagen and extracellular matrix components. This leads to scar tissue formation and functional tissue destruction, resulting in kidney failure.

Researchers have delved into noninvasive diagnostic methods of renal fibrosis (RF) in chronic kidney disease, including ultrasound (US), magnetic resonance imaging (MRI), and radiomics. However, the value of these diagnostic methods in the …

Our study highlights some of the limitations of using interstitial fibrosis to predict who will develop end-stage renal disease (ESRD). Methods: Analysis of 434 consecutive renal biopsies performed between 2001 and 2012 at a single center.

2006年1月2日 · Renal fibrosis, characterized by glomerulosclerosis and tubulointerstitial fibrosis, is the final common manifestation of a wide variety of chronic kidney diseases (CKD).

Interstitial fibrosis is a hallmark structural correlate of progressive and chronic kidney disease. There remain many uncertainties about how to best measure interstitial fibrosis both in research settings and in evaluations of renal biopsies performed for management of individual patients.

1999年12月1日 · The mechanisms that contribute to these two types of matrix accumulation in the kidney are in part common, but to some extent also different. In this brief editorial, we focus on some new approaches to interstitial fibrosis that have recently helped to …

Purpose of review: Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IFTA) as the final common pathway. …