Monoclonal gammopathy of undetermined significance (MGUS) is a disorder in which there is an increased production and accumulation of an abnormal protein, monoclonal protein (M protein), by plasma cells in the bone marrow [1]. There are two subtypes of …

2024年12月20日 · Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an atypical protein is found in the blood. The protein is called monoclonal protein or M protein. This protein is made in the soft, blood-producing tissue in the center of bones.

Monoclonal gammopathy of undetermined significance is one of the most common pre-malignant disorders. IgG and IgA monoclonal gammopathy of undetermined significance are precursor conditions of multiple myeloma; light-chain monoclonal gammopathy of ...

The most common condition linked with these abnormal proteins is monoclonal gammopathy of undetermined significance (MGUS). It's not cancer. However, people with MGUS may have a greater risk of getting serious diseases of the bone marrow and blood.

2022年4月8日 · In the first of three scenarios, the patient is found to have an immunoglobulin (Ig) G kappa monoclonal gammopathy measuring 2.2 g/dL, serum free light chains reveal a kappa/lambda ratio of 24, and a bone marrow biopsy reveals 15% kappa-restricted plasmacytosis.

Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder.

Monoclonal gammopathy of clinical significance (MGCS) is a recently recognized clinical-pathological entity. Symptoms are caused by the presence of a monoclonal protein leading to high comorbidity. The affected organs vary according to the target ...

2024年10月12日 · There are two types of light chains, called kappa and lambda. The most common type of M protein in myeloma is IgG. High levels of IgM suggest you may have Waldenstrom's macroglobulinemia.

2019年4月1日 · An M protein may consist of an intact immunoglobubin (Ig) molecule — i.e., two light chains and two heavy chains (most commonly IgG type followed by IgA and IgM) — or a light chain only (kappa or lambda).

Monoclonal Gammopathy of Undetermined Significance (MGUS) is an asymptomatic condition that is included in a spectrum of monoclonal plasma cell disorders (dyscrasias).