Statins (also called HMG-CoA reductase inhibitors) block an enzyme called HMG-CoA reductase that is involved in making cholesterol. Specifically, statins block the synthesis of mevalonate, which is a precursor to sterols such as cholesterol.

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are antilipemic agents that competitively inhibit HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, an early precursor of cholesterol.

2024年5月6日 · Zocor belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Zocor is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

2023年7月25日 · Rosuvastatin works by blocking an enzyme in the liver known as HMG-CoA reductase that is responsible for the conversion of HMG-CoA to mevalonate, an important substance necessary for the synthesis of cholesterol and coenzyme Q10.

2024年9月26日 · Several cases of serious fetal abnormalities were reported in 2 series of 178 and 143 cases among pregnant women taking a HMG-CoA reductase inhibitor (statin) during the first trimester of pregnancy. These included limb and neurological defects, …

2024年2月26日 · Caution should be exercised when HMG-CoA reductase inhibitors and azole antifungals are prescribed concurrently. Exposure to HMG-CoA reductase inhibitors is associated with a decreased risk of bone fractures in persons older than 50.

2023年10月12日 · Lipitor (atorvastatin) belongs to a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Two series of pregnant women who took an HMG-CoA reductase inhibitor (n=178 and n=134) during the first trimester of pregnancy, found serious fetal abnormalities in several cases including limb and neurological defects, spontaneous abortions, and fetal deaths.

2025年1月14日 · Lovastatin is a specific inhibitor of HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway for cholesterol.

The use of most HMG-CoA reductase inhibitors is contraindicated in patients with active liver disease, decompensated cirrhosis, or unexplained persistent elevations of serum transaminases. HMG-CoA reductase inhibitors are extensively metabolized by the liver.