2023年7月10日 · Salicylate toxicity is a medical emergency. Intentional ingestion or accidental overdose can cause severe metabolic derangements making treatment difficult. Co-ingestion of other medications can further complicate management.

2021年10月1日 · Acid-base status can suggest salicylate toxicity, but cannot exclude it. Note also that patients with co-ingestion may not manifest with classic acid/base patterns (e.g., aspirin plus opioids may not lead to a respiratory alkalosis).

2020年11月3日 · Salicylates in acute overdose classically cause a respiratory alkalosis by stimulating the respiratory centres in the brain followed by a metabolic acidosis by uncoupling oxidative phosphorylation. The classic triad of mild toxicity is nausea, vomiting and tinnitus,

Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. [1] Early on, these may be subtle, while larger doses may result in …

2023年11月13日 · This topic will discuss the clinical manifestation and evaluation of salicylate overdose and toxicity in children and adults. A rapid overview table to facilitate emergency management is provided ( table 1 ).

Acute ingestion of > 150 mg/kg of salicylate can cause severe toxicity. Salicylate tablets may form bezoars, prolonging absorption and toxicity. Chronic toxicity can occur after several days or more of high therapeutic doses; it is common, often undiagnosed, and often more serious than acute toxicity. Chronic toxicity tends to occur in older ...

2020年6月24日 · This article highlights the risk factors for salicylate toxicity; reviews the pathophysiological effects; notes the hidden sources of salicylates, including foods, drugs, and topical ointments...

Salicylate toxicity is a complex problem that may develop with either acute or chronic exposure to salicylates. Salicylates are found in over-the-counter medications including aspirin, bismuth subsalicylate, effervescent antacids, ointments, liniments, and oil of wintergreen (methyl salicylate) and alternative medication products (e.g., willow ...

A high index of suspicion of salicylate toxicity is necessary, with prompt recognition of clinical signs and symptoms of salicylate poisoning, such as tinnitus, hyperventilation,...

2018年5月9日 · Definition: Salicylate toxicity is characterized by a constellation of symptoms caused by acute or chronic overdose of salicylate containing compounds. The most common salicylate is aspirin, but the group also includes topical forms of salicylates, methyl salicylate (Oil of Wintergreen), and bismuth subsalicylate (such as in Pepto-Bismol).