Receptors present on acinar cells, particularly those for cholecystokinin and secretin, have been better characterized as to the molecular nature of the ligand-receptor interaction. Other reports have described the potential regulation of acinar cells by GLP-1 and cannabinoids.

Acinar cell carcinoma (ACC) is a rare pancreatic malignancy with distinctive clinical, molecular, and morphological features. The long-term survival of ACC patients is substantially superior to that of pancreatic adenocarcinoma patients.

The acinar cell of the exocrine pancreas has the greatest rate of protein synthesis of any mammalian organ. The acinar cell has a highly developed endoplasmic reticulum (ER) system combined with mechanisms to modify and transport newly synthesized proteins through the secretory pathway [2, 26].

Although acinar cells constitute approximately 80% of the pancreatic parenchyma, acinar cell carcinoma of the pancreas is a rare malignancy, accounting for 1% of pancreatic exocrine tumors and occurs primarily in men. This neoplasm is occasionally associated with a syndrome of subcutaneous and intraosseous fat necrosis and polyarthralgia due to ...

Recent advances focus on signals dictating pancreatic development, acinar cell fate, pancreatic growth, and secretion. Regeneration of acinar cells after pancreatitis depends on expression of embryonic signals in mature acinar cells.

We have reviewed information gained at the cellular level concerning structural and functional relationships, the effects of fasting and feeding, as well as the action of gastrointestinal hormones and cholinergic agonists on acinar cells.

2023年8月4日 · The acinar cell is the key element in the exocrine pancreas, producing and secreting the enzymes needed for the digestion of food. The secretory process is tightly regulated by the neurotransmitter acetylcholine, released from …

2013年3月19日 · Pancreatic acinar cells form a basic structure called an acinus that surrounds a central lumen open to the duct system. Pancreatic acinar cells produce, store and secrete enzymes necessary...

2025年2月6日 · Characterization of the vascular heterogeneity within the pancreas has previously been lacking. Here, we develop strategies to enrich islet-specific endothelial cells (ISECs) and acinar-specific ...

The pancreatic acinar cell synthesizes, stores, and secretes the proenzymes and enzymes needed to digest dietary proteins, carbohydrates, and lipids. Meeting these functional requirements necessitates that the acinar cell has very high rates of protein synthesis and export.