2010年10月11日 · Homeobox gene interactions become exponentially complex as the multidimensional nature of gene regulatory networks is explored. However, it has given rise to an entirely new perspective on developmental biology and molecular genomics.

1997年10月1日 · Homeobox genes are master developmental control genes that act at the top of genetic hierarchies regulating aspects of morphogenesis and cell differentiation in animals. These genes...

Homeobox genes are characterized by a conserved 180-bp DNA sequence coding for a 60-aminoacid DNA-binding domain called the ‘homeodomain’. They function as transcription factors recognizing specific DNA sequences and regulate target genes (McGinnis and Krumlauf, 1992; Quiring et al., 1994).

2022年5月14日 · Antp and Ubx are two of 8 homeobox genes that are linked in a cluster on one Drosophila chromosome. All of them encode transcription factors, each with a DNA-binding homeodomain and act in sequential zones of the embryo …

2023年12月20日 · Homeobox genes are a class of genes that play a critical role in the regulation and development of various biological processes. These genes encode for homeodomain-containing proteins, which are transcription factors that bind to specific DNA sequences to control gene expression.

2020年3月16日 · Homeobox genes are a group of genes that regulate development in multicellular organisms; this includes cell differentiation and morphogenesis. They were first discovered in the fruit fly...

Many homeobox genes encode transcription factors with regulatory roles in animal and plant development. Homeobox genes are found in almost all eukaryotes, and have diversified into 11 gene classes and over 100 gene families in animal evolution, and 10 to 14 gene classes in plants.

2024年3月18日 · This year, 2024, marks the 40th year of the discovery of the homeobox, a landmark discovery that fundamentally impacted multiple fields, ranging from genetics and genomics to developmental biology, neuroscience and evolution.

Homeobox refers to a conserved DNA sequence responsible for encoding a 60-amino acid protein motif called the homeodomain. This domain functions as a helix-turn-helix DNA-binding motif, allowing homeobox genes to act as transcription factors in various developmental processes across different organisms.

2000年11月10日 · Homeobox proteins are transcription factors that regulate the expression of lineage-specific genes and can control cell and organ differentiation. Homeobox genes are also involved in cell cycle control, and some are oncogenes.