2022年4月18日 · About 2 in 3 people with AAG have high levels of antibodies called ganglionic acetylcholine receptor antibodies (g-AChR antibodies). Researchers think that your g-AChR antibody levels correlate to how severe your symptoms are.

Nicotinic ganglionic acetylcholine receptor antibody (α3-AChR Ab) values detected in 155 patients with neurological disease (those referred for paraneoplastic evaluation) and 457 controls (those with cancer only or those without neurological disease or cancer).

2000年9月21日 · Autoantibodies specific for nicotinic acetylcholine receptors in the autonomic ganglia are potentially pathogenic and may serve as serologic markers of various forms of autoimmune autonomic...

Autoimmune autonomic ganglionopathy (AAG) is a disease of autonomic failure caused by ganglionic acetylcholine receptor (gAChR) autoantibodies. Although the detection of autoantibodies is important for distinguishing the disease from other ...

Autoimmune autonomic ganglionopathy is a type of immune-mediated autonomic failure that is associated with antibodies against the ganglionic nicotinic acetylcholine receptor present in sympathetic, parasympathetic, and enteric ganglia.

Nicotinic acetylcholine receptors (AChR) are ligand-gated cation channels that are present throughout the nervous system. The ganglionic (α3-type) neuronal AChR mediates fast synaptic transmission in sympathetic, parasympathetic and enteric autonomic ganglia.

Nicotinic ganglionic acetylcholine receptor antibody (α3-AChR Ab) values detected in 155 patients with neurological disease (those referred for paraneoplastic evaluation) and 457 controls (those with cancer only or those without neurological disease or cancer).

Autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder that leads to autonomic failure. The disorder is associated with autoantibodies to the ganglionic nicotinic acetylcholine receptor (gAChR).

2020年2月16日 · We have established luciferase immunoprecipitation systems to detect antibodies against gAChR in the past and determined the prevalence of gAChR antibodies in various autoimmune diseases including AAG and rheumatic diseases. Autonomic dysfunction, which affects lower parasympathetic and higher sympathetic activity, is usually observed in ARD.

2021年1月29日 · Autoantibodies against the ganglionic acetylcholine receptor (gAChR) have been reported in a minority of patients with POTS, but the prevalence and clinical relevance is unclear. Clinical information and serum samples were systematically collected from participants with POTS and healthy control volunteers (n = 294).