ERAD: the long road to destruction - Nature Cell Biology
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or unassembled proteins from the ER. ERAD targets are selected by a quality control system within...
Mechanisms of substrate processing during ER-associated protein ...
2023年8月1日 · Soluble proteins in the ER lumen are primarily routed to the HRD1 E3 complex, whereas integral membrane proteins are processed via multiple ER-associated protein degradation (ERAD) paths.
Structural basis of ER-associated protein degradation ... - Science
2020年4月24日 · ERAD-L is mediated by the Hrd1 complex (composed of Hrd1, Hrd3, Der1, Usa1, and Yos9), but the mechanism of retrotranslocation remains mysterious. Here, we report a structure of the active Hrd1 complex, as determined by cryo–electron microscopy analysis of …
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
2024年2月16日 · Proteomic screens of SEL1L and HRD1 interactomes reveal that SEL1L-HRD1 interaction is a prerequisite for the formation of a functional HRD1 ERAD complex, as SEL1L is required for the...
The cryo-EM structure of the human ERAD retrotranslocation complex …
2023年10月13日 · We determined the cryo-EM structures of the hetero-decameric complex formed by the Derlin-1 tetramer and the p97 hexamer. It showed an intriguing asymmetric complex and a putative coordinated squeezing movement in Derlin-1 and p97 parts.
Endoplasmic-Reticulum-Associated Protein Degradation
Endoplasmic reticulum-associated protein degradation (ERAD), or ER-associated protein degradation, is a process in which the proteins in the ER are retrotranslocated (or “dislocated”) to the cytosol for proteasomal degradation.
The ERAD system is restricted by elevated ceramides
2023年1月13日 · The ERAD complex exists within the ER lipid bilayer and controls the degradation of many lipid biosynthetic enzymes in the related sterol synthesis pathway. We propose that in certain cases, the ERAD systems would be …
Endoplasmic Reticulum-Associated Degradation (ERAD)
2019年2月5日 · ERAD is a complex, multistep process starting with the recognition and targeting of substrates, followed by ubiquitination, retrotranslocation and proteasomal degradation. A large number of ERAD factors functioning in different molecular machineries increases the complexity of mammalian ERAD.
Order through destruction: how ER‐associated protein …
2022年2月16日 · The yeast ERAD branch defined by the Doa10 complex, composed of the ubiquitin ligase Doa10 and the ubiquitin conjugation enzymes Ubc6 and Ubc7, was initially identified through its role in degradation of the soluble …
The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex …
2016年9月6日 · Endoplasmic reticulum (ER)-associated degradation (ERAD) is a principal mechanism that targets ER-associated proteins for cytosolic proteasomal degradation. Here, our data demonstrate a critical role for the Sel1L-Hrd1 complex, the most conserved branch of ERAD, in early B cell development.
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