Extraembryonic trophoblast lineages constitute the placenta, and are essential for individual development. In human early embryo development, these cells can be generated from totipotent blastomeres.

Conventional human pluripotent stem cells at the primed pluripotent state are capable of generating all the embryonic lineages. However, their ...

Advanced maternal age (AMA) placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms of trophoblast ...

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University (L. Liu, Q.G., Y.C., S.C., L ...

It combines a monoclonal antibody, datopotamab, that targets trophoblast cell surface antigen 2 (TROP2), a protein commonly found in high levels on breast cancer cells, with the chemotherapy drug ...

Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine kinases to regulate a wide range of biological processes during development and adulthood. FGF receptors (FGFRs) are involved ...

The drug’s active agent, datopotamab deruxtecan, is a monoclonal antibody–drug conjugate that binds to trop-2, a trophoblast cell surface antigen expressed by some tumor cells. This causes the ...

Life Sciences Ontario (LSO) proudly announces the recipients of the 2025 LSO Awards, celebrating excellence and innovation in life sciences. Now in its 22nd year, the LSO Awards continues its ...

Galectins constitute a phylogenetically conserved family of soluble β-galactoside binding proteins, which contribute to placentation by regulating trophoblast development, migration and invasion, ...

摘要本文针对2024年国内外晚期非小细胞肺癌（NSCLC）取得的临床进展进行回顾。在靶向治疗领域，特别是针对罕见突变的研究，继EGFR、ALK、ROS1等突变后的新靶点，KRAS ...

Pre-Market: 8:06:16 a.m. EST ...