Recent advances in synaptic proteome approaches, such as fluorescence-activated synaptosome sorting (FASS) and proximity labeling, have allowed for a detailed and spatial analysis of many ...

also called synaptobrevin), syntaxin and synaptosome-associated protein of relative molecular mass 25,000 (SNAP-25)) are the precise and select targets of the clostridial botulinum and tetanus ...

在微观的细胞世界里，细菌与人体免疫系统时刻都在上演着一场激烈的 “战争”。胞内细菌病原体十分狡猾，它们能躲避免疫系统的监视，偷偷藏在宿主细胞内疯狂繁殖，引发各种疾病，对公众健康构成了严重威胁。巨噬细胞作为免疫系统的 “卫士”，会启动多种免疫反应来对抗入侵的病原体，其中细胞自噬（xenophagy）是巨噬细胞抑制胞内病原体存活的重要机制。在细胞自噬过程中，自噬体就像一个 ...

Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have ...