Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...
Dr O Hardiman, Department of Neurology, Beaumont Hospital, and Trinity College Institute for Neuroscience, Trinity College Dublin, Dublin 9, Ireland; ohard{at}iol.ie Background: We conducted a ...
3 Working Group ‘Deep Brain Stimulation in Psychiatry: Guidance for Responsible Research and Application’. This Working Group is organised by the Europäische ...
Parkinson’s disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or ...
As a chronic progressive disease, Parkinson's disease (PD) has a presymptomatic interval; that is, a period during which the pathological process has begun, but motor signs required for the clinical ...
Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, ...
Correspondence to Professor Yong-Ping Chen, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Yongping.chen{at}wchscu.cn Background Alzheimer’s disease (AD) is ...
Correspondence to Dr M Braschinsky, Department of Neurology, University of Tartu, Puusepa 2, Tartu 51014, Estonia; mark.braschinsky{at}kliinikum.ee Background Hereditary spastic paraplegia (HSP) ...
Adult-onset leukodystrophies and genetic leukoencephalopathies comprise a diverse group of neurodegenerative disorders of white matter with a wide age of onset and phenotypic spectrum. Patients with ...
Movement disorders arise from the complex interplay of multiple changes to neural circuits. Successful treatments for these disorders could interact with these complex changes in myriad ways, and as a ...
University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical ...
Mrs J M Hadfield, Department of Emergency Medicine, Hope Hospital, Stott Lane, Salford M6 8HD, UK. emailjhadfield{at}gen.srht.nwest.nhs.uk OBJECTIVES To determine whether the presence and severity of ...