Structure-based drug design is the design and ... Previously, authors have identified GW461484A (GW) as an inhibitor of the kinase Yck2 in the fungal pathogen Candida albicans.

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China ...

Astronomers have discovered what may be the largest-scale structure in the known universe — a group of galaxy clusters and clusters of galaxy clusters that spans roughly 1.3 billion light-years ...

Here, we describe how the extracellular signal-regulated kinase (ERK) pathway in osteoblasts controls bone formation by suppressing the mechanistic target of rapamycin (mTOR) pathway. We also show ...

In keeping with previous structures of ATM and its yeast homolog Tel1, the dimeric human ATM kinase adopts a symmetric, butterfly-shaped structure. The conformation of the ATM kinase domain is most ...

In mammalian cells, mTOR forms two complexes with distinctive structure and functions, namely mTORC1 and mTORC2 ... can inhibit cell growth and proliferation via its target genes, such as the ...

Secondly, AMPK can also activate TSC1/TSC2 complex and inhibit mTORC1 activity as described above. Therefore, unlike the PI3K, AMPK restrains the mTOR function. Rapalogs can combine the FKBP12 and ...

Murine hematopoietic cells were transduced with ecotropic supernatants (Figure 1b), using conditions that led to efficient gene marking with low provirus copies (<3) per cell. 23 Polyclonal ...