Mechanistic target of rapamycin (mTOR) inhibitors and Rho-associated coiled-coil kinase 2 (ROCK2) inhibitors target unique kinase pathways that affect immune cells. ROCK2 inhibitors affect Rho ...

Structure-based drug design is the design and ... Previously, authors have identified GW461484A (GW) as an inhibitor of the kinase Yck2 in the fungal pathogen Candida albicans.

bham.ac.uk Background The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an intracellular lipid kinase ... B cells and in the lymph node on the CD4/CD8 ratio (online supplementary ...

Plants are very important living things. They have lots of jobs, such as providing animals with food and releasing oxygen into the air. To survive and carry out these jobs, they all need three ...

Fifteen lean (BMI: 22.1 ± 0.5 kg/m2) and fourteen obese (40.6 ± 1.4 kg/m2) men and women were recruited to undergo an oral glucose tolerance test (OGTT) and skeletal muscle biopsies. Characteristics ...