A retrospective study of patients with carbapenem non-susceptible infections and limited treatment options at 24 US hospitals ...

Background: Although imipenem/cilastatin (IMI/CIL) has demonstrated favorable therapeutic efficacy against various infections, the incidence of potential adverse events (AEs) has escalated in parallel ...

Notably, resistance to ampicillin was found in 68.2% of isolates, while resistance to imipenem remained relatively low at 1.6%. Additionally, resistance to cefoxitin and chloramphenicol ...

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, ...