EGFR functions by activating many intracellular signaling pathways following binding of various ligands to the receptor. Several of these signaling pathways, such as phosphatidylinositol 3-kinase, are ...

Ubiquitin-binding domains (UBDs ... and the endocytic regulators epidermal growth factor receptor substrate 15 (EPS15) and EPS15-related (EPS15R). Interestingly, Vps27, a yeast homologue of ...

The strength of theoretical approaches is in the simplification of complex biological systems. We here consider the general problem of receptor–ligand binding in the context of antibody–antigen ...

A research team revealed that insulin-like growth factor-binding protein 6 (IGFBP6) serves as a potential therapeutic target for suppressing endothelial inflammation and atherosclerosis.

human epidermal growth factor receptor (HER) 2; HER3; and HER4. Upon ligand binding, these receptors can homodimerize or heterodimerize with each other to form several receptor combinations.

Get Instant Summarized Text (Gist) The angiogenic growth factor adrenomedullin 2 (ADM2) has been shown to alleviate anxiety-like behaviors in mice by enhancing the integrity of the blood-brain ...

Most practicing sports medicine clinicians refer to the concept of “inflammation” many times a day when diagnosing and treating acute and overuse injuries. What is meant by this term? Is it a “good” ...

Blood urea nitrogen (BUN): Urea nitrogen, also measured in the blood, is removed by the kidneys. Levels above 25 mg/dL are suggestive of kidney failure. Glomerular filtration rate (GFR): This number ...