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Novel vaccine concept generates immune responses that could produce multiple types of HIV neutralizing antibodies
They vaccinated rhesus macaque monkeys and mice with those immunogens and elicited ... priming the immune system to elicit a bNAb called VRC01. This bNAb was discovered by NIAID researchers ...
Nature4y
Glycan-masked Engineered Outer Domains of HIV-1 GP120 and Their Use: Collaborative and Licensing Opportunity
which elicits VRC01-class precursors in multiple transgenic mouse models. However, a large proportion of the antibodies elicited by eOD-GT8 60mer are non-CD4bs or “off-target” antibodies ...
Nature4y
N6, A Novel, Broad, Highly Potent HIV-specific Antibody
This allows N6 to tolerate changes in the HIV envelope, including the attachment of sugars in the V5 region, a major mechanism by which HIV develops resistance to other VRC01-class antibodies.N6 ...