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SUMOylation 修饰在前列腺癌研究中的重大突破:从机制到治疗新希望
抑制 SENP1 的化合物如雷公藤甲素(Triptolide)和苦瓜素 Ic(Momordin Ic)能抑制前列腺癌细胞的增殖。 研究结论表明,SUMOylation 修饰与去 SUMOylation 修饰之间的平衡对前列腺癌的进展至关重要。SUMOylation 修饰既可以作为致癌驱动因素,也具有潜在的肿瘤抑制作用 ...
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