The tricyclic antidepressants have a higher rate of Q-T interval prolongation than do selective serotonin-reuptake inhibitors (SSRIs), particularly at higher concentrations and in cases of overdose.
Depression is a pervasive mental health condition affecting millions of people worldwide. It can manifest in various ways, from persistent sadness to a lack of energy or interest in daily activities.
Antidepressants may also be helpful in managing urinary incontinence (unintentionally passing urine) and stress incontinence (passing urine when there’s pressure on the bladder from coughing, jumping, ...
TCAs have been on the market the longest — since the 1950s — and may cause more side effects than newer antidepressants. They are usually prescribed only when other antidepressants haven't ...