Based on the structural conservation of the RNAP core enzyme, the ribosome, and the universally conserved elongation factors Spt5 (NusG) and NusA, we discuss requirements and functional implications ...

We posit that epigenetic factors are critical in small airways disease in COPD ... which recognise and interact with acetylated histones to initiate and maintain transcriptional elongation.14 All ...

Post-transcriptional modifications of mitochondrial RNAs (mtRNAs ... ATP-dependent RNA helicase SUV3, mitochondrial; TEFM, Transcription elongation factor, mitochondrial; TFAM, Transcription factor A, ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

Cells navigating in complex microenvironments frequently encounter narrow spaces that physically challenge migration.

The HUMANOID Center at UC San Diego is pioneering organoid research aimed at improving the reliability and reproducibility of ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

Elongation was most pronounced in the proximal descending aorta, which showed an almost 2.5-fold length increase during life. The lengthening of the thoracic aorta was accompanied by a marked change ...

This important study presents compelling observational data supporting a role for transcription and polysome accumulation in the separation of newly replicated bacterial chromosomes. The study is ...

Factors are numbers that divide exactly into a number. They are the multiplication “facts” of the number. A common factor is a factor that is shared by two or more numbers. The number 1 will ...