The paradigm of stellate cell activation provides an important framework for defining therapeutic targets. Hepatic fibrosis is a wound healing response comprising reversible scarring that occurs ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

We established and characterised two human HSC cell lines termed LX-1 and LX-2, and compared their features with those of primary human stellate cells. Methods and results: LX-1 and LX-2 were ...

jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...

First wash off the foot, hand or other punctured skin with soap and water. Then soak the puncture wound in warm soapy water for 15 minutes. For any dirt or debris, gently scrub the wound surface back ...

Igloo coolers are being recalled after multiple fingertip amputations, bone fractures and lacerations. The cooler is the Igloo 90 Qt. Flip and Tow Rolling Coolers. The tow handle on the rolling ...

Tissue-resident immune cells reside in distinct niches across organs, where they contribute to tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Innate lymphoid ...

The skin, being a multifaceted organ, performs a pivotal function in the complicated wound-healing procedure, which encompasses the triggering of several cellular entities and signaling cascades.

Objectives In the complex panorama of autoimmune diseases, the characterisation of pivotal contributing autoantibodies that are involved in disease progression remains challenging. This study aimed to ...