Damaged lysosomes are eliminated by lysophagy, yet the regulatory mechanisms of this process are not fully defined. Here, the authors identify that the TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis is ...

ubiquitylation of lysines and sumoylation of lysines. Histone modifications are proposed to affect chromosome structure and function, for instance during transcription and chromatin remodelling ...

Here we address this question by examining regulatory elements of Srs2, such as its phosphorylation, sumoylation, and protein-interaction sites. Our genetic analyses and checkpoint level assessment ...

Regulatory features of Srs2 and corresponding mutants. (A) Schematic of Srs2 protein domains, regulatory features, and mutations affecting each of its features. Cdk1 phosphorylation sites depicted ...

【导读】SUMOylation在肿瘤发生过程中的重要性已受到越来越多的关注，针对这一途径的治疗药物研究也取得了进展。然而，SUMOylation在肝细胞癌 ...