Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...

Key among these is the activation of signaling by RHO (another member of the RAS superfamily) and the up-regulation of kinases, some of which have the same substrates as ERK. Studies are needed to ...

1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill ...

"Some people may leave our platforms for virtue signaling, but I think the vast majority and many new users will find that these changes make the products better." Zuckerberg was replying to a ...

The authors declared no competing interests. Cite this: The Role of Hormonal Therapy in the Management of Hormonal-Receptor-Positive Breast Cancer With Co-Expression of HER2 - Medscape - Sep 01 ...

Figure 2. Schematic diagram depicting the expression of ligands and receptors within the different cellular compartments of the intestinal crypt during normal homeostasis and following regeneration.

Figure 1: a, Sequence alignment of SAM domains from the Eph family of receptor tyrosine kinases and selected ... other protein interaction modules with signaling functions such as SH3, SH2 ...

This unique mechanism allows avutometinib to block MEK signaling without the compensatory ... focal adhesion kinase family of non-receptor protein tyrosine kinases. FAK and Pyk2 integrate signals ...

Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University, Otsu, Shiga 520-0811, Japan Key Laboratory of Industrial Ecology and Environmental Engineering ...

This is a fundamental study that addresses the key question of how the tetraspanin Tspan12 functions biochemically as a co-receptor for Norrin to initiate β-catenin signaling. The strength of the work ...

Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that ...