Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... elucidating the unique biochemical requirement for a 2’-PO 4 in the ligation step of ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

1 Alternative splicing will sometimes introduce a premature stop codon into an mRNA, which NMD will recognize as an mRNA that needs to be degraded. “It's a very common mechanism of downregulation,” ...

CUGexp RNA forms based-paired structures that bind and sequester MBNL protein ... We are using three experimental systems to identify previously unknown roles for coordinated alternative splicing and ...

To do this, this large protein-RNA complex, which is located in the ... recognizes faulty processes and subsequently aborts ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

"By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism," said co-corresponding author Robert Spitale ...

In this webinar, Dr. Megan L Noonan will present her research on the role of alternative splicing in kidney disease progression, discussing how she used nanopore RNA sequencing to accurately detect ...