SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Pyruvate dehydrogenase kinase 1 (PDHK1), as an inhibitor of Pyruvate dehydrogenase ... In the oxidative phosphorylation (OXPHOS) pathway, Carnitine palmitoyltransferase 1 (CPT1) enhances this process, ...

CCM Biosciences has developed groundbreaking compounds that activate the enzyme SIRT3, potentially reversing age-related cellular decline. These first-in-class drugs outperform existing treatments and ...

Mechanistically, SLC13A2 promotes import of citrate into hepatocytes, serving as building block for ACLY-dependent acetyl-CoA formation and de novo synthesis of cholesterol. In line, the ...

This enzyme could be transformative for industry, it not only speeds up a crucial class of chemical transformation, but does so with remarkable precision, even when working with challenging chemical ...