Here the authors characterise THAP1 as a transcriptional activator of PSMB5, suggesting that proteasome dysfunction might underlie the pathogenesis of THAP1 dystonia.

or “Can the 20S proteasome degrade tau without a proteasome activator?”), using machine learning to process the content and context of literature, and using large language models to suggest relevant ...

The ubiquitin-proteasome system (UPS) is a non-lysosomal proteolytic pathway involved in numerous ... resulting in expression of truncated Notch characterized by constitutive Notch signaling ...

Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk 80-308, Poland ...

Objectives To determine whether the process of ubiquitination and/or activity of the 26S proteasome are involved in the induction of osteoarthritis (OA). Methods Bovine cartilage resorption assays, ...

Nurix Therapeutics, Inc. stock slid 40% after promising NX-5948 results in CLL. NX-5948 shows efficacy in heavily pre-treated ...

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University (L. Liu, Q.G., Y.C., S.C., L ...

Popular Windows activator tool MAS (Microsoft Activation Scripts) has been updated to v3.0 with TSforge, the developer group’s most powerful activation exploit yet. With TSforge, MAS can ...

Compiled for Windows x86 (Win32) using MSVC++ v14.29 in Visual Studios 2019 .NET Framework 4.0 and Windows SDK 10.22000.0.