The paradigm of stellate cell activation provides an important ... way to eliminate hepatic fibrosis is to clear the primary cause of liver disease. The latter includes abstinence in the case ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are ... including primary cultures and hepatic zone-specific endothelial cell isolations.

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...