The authors use an impressive array of techniques (including highly challenging presynaptic recordings) to show that GPR55 activation reduces the readily releasable pool of vesicle without affecting ...

Assuming that the newly formed spines are indeed functional, another important question arises: what is the computational implication of having multiple spines connecting to the same presynaptic ...

State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China ...

Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai 200444, People’s Republic of China National Center for Translational Medicine (Shanghai) SHU Branch, ...

This applies in particular to the presynaptic part where neurotransmitter is released from synaptic vesicles, which in turn have to be recycled and refilled in a complex membrane trafficking cycle.

We observed a more than 2-fold increase in the mean number of dense core vesicles (DCVs) in the presynaptic compartment of excitatory synapses and an almost 20-fold increase in the number of DCVs in ...