Small molecules are low molecular weight molecules that include lipids, monosaccharides, second messengers, other natural products and metabolites, as well as drugs and other xenobiotics.

Drug addiction is a condition in which there is uncontrolled use of a substance with a harmful outcome. Drugs overstimulate the brain’s reward circuit, producing pleasure or euphoria. With repeated ...

The latter (arthropods) category will not be considered here. Among various side effects, antiparasitic drugs may alter the host immune components. Few antiparasitic drugs appear to be safe in ...

It can occur with prescription or nonprescription drugs. It can also range from mild to severe. Substance use disorder, formerly known as “drug abuse,” develops when substance use interferes ...

Fifteen years ago, an analysis of drug molecules moving through the stages of clinical development suggested that increased three-dimensional character was a marker of greater success. Now ...

The authors surveyed nearly 350 people about how many attempts it took to quit a substance before they were finally able to maintain their sobriety - revealing which drugs could be the most addicting.

which aims to chart out the fundamental rules of how drug molecules bind with and influence their biological targets. “This is exactly the kind of ambitious, transformative project that becomes ...

Criticism over how the Chinese government buys drugs for its public health care system has ignited frustration over the quality of medicine. By Alexandra Stevenson and Zixu Wang Reporting from ...

It’s time to move on from treating heroin as Europe’s main drug problem, according to the head of the European Union’s drugs agency. That’s not to say heroin isn’t still a major problem.

Top doctors raised concerns about domestically made drugs, saying Beijing’s effort to lower costs is sacrificing quality. By Alexandra Stevenson and Zixu Wang Reporting from Hong Kong A rare ...

Using AI to discover, or design, the building blocks of drugs is a fast-growing area of research. Another team of scientists out of Philadelphia is using AI to discover new antibiotics by resurrecting ...