In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The DNA-damaging agent Gemcitabine (GEM) is a ...

Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, United States Department of Psychiatry, Weill Institute for Neuroscience, University ...

Drug´s effect on proliferation was tested by MTT assays and cell death was assessed by Anexin V-PI apoptosis assays. The presence of DNA double-strand breaks was analyzed by phospho-H2AX fluorescent ...

Primary antibodies: rabbit anti-phosphor-AMPK (α, phospho Thr172; 1:200, Abcam, ab23875), rabbit anti-phospho-histone H2AX (phospho Ser139; 1:200, Abcam, ab2893), rabbit anti-phospho-histone H3 ...