The main and best characterized mechanisms involved in NK cell-mediated cytotoxicity are the granule exocytosis pathway (perforin/granzymes) and the expression of death ligands. These pathways are ...

with various defects in the perforin–granzyme cell-death pathway. Secondary (nonmendelian) HLH is an acquired condition, mainly seen in adults, that is most often triggered by infections ...

They enter target cells with the help of perforin to induce programmed cell ... and experiments defining Gzm-activated proinflammatory pathways may be a promising direction to determine the ...

Korah leads a rebellion against Moses and Aaron; plague sent by God; Aaron’s rod; duties for priests; the tithe offering Korah, Dathan, and Abiram rose up before Moses, with certain of the children of ...

Sharing the pathway safely means leaving a minimum of one meter between yourself and the person that you are passing. When you’re cycling or riding a scooter on a pathway and you approach others from ...

Apoptosis can be triggered by the immune system or by the interaction of viral proteins with host signalling pathways. Inhibition of apoptosis has mixed effects on viral titre but typically has a ...