the authors used a combination of in vivo and ex vivo experiments in mice to demonstrate ligand-independent activation of Notch1 by circulation induced-mechanical stress and provide evidence for ...

What is Pathway to Purdue Agriculture? Pathway to Purdue Agriculture is a partnership between the Purdue University College of Agriculture and Ivy Tech Community College-Lafayette designed to help ...

The current foci of diabetic neuropathy research are oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway. Figure 1 provides an overview of how ...

and ROS activation will cause PKC pathway activation (47, 48). So, we next examined the PKC effects in dopamine D1/D5 receptor activation. The PKC blocker and activator were used. The PKC-blocker ...

Conclusion: Activation of TRPV1 by exogenous agonists can increase the expression and function of NKCC1 protein in DRG, which is mediated by activation of PKC/p-ERK signaling pathway. These results ...