PARP-1 is an enzyme directly involved in repairing single-stranded DNA breaks. It senses single-stranded DNA breaks through a zinc-finger DNA-binding domain, binds to the sites of breaks and ...

Eikon’s EIK1003 selectively inhibits PARP1 with the goal of offering the same efficacy as currently available PARP inhibitors while avoiding the toxicity of those drugs. EIK1003 is in Phase 1 ...