pH 7.4), human liver microsomes (175 pmol cytochrome P450/500 μL) or rhCYP3A4 (10 pmol CYP3A4/500 μL) and a NADPH-generating system. For inhibition studies, the reaction mixture was pre-incubated with ...

很多人知道高血压患者需要服用降压药来控制血压，但你有没有想过，降压药和某些食物，尤其是柚子，之间会有什么样的“化学反应”呢？ 这个问题听起来可能有点吓人，但实际上，吃柚子真的会影响降压药的效果吗？

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...

60岁的老刘是个典型的“药罐子”，每天一早一晚都要按时服用降压药，但最近一段时间，他发现自己的血压有点不听话，药效似乎越来越差。起初，他以为是换季引起的波动，直到一次定期体检时，医生详细询问了他的饮食习惯，才发现问题的根源。

CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of ...

Expert Rev Endocrinol Metab. 2010;5(5):653-662.