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Methylation of cytosines in CpG dinucleotides ... For every successful nucleotide incorporation, pyrophosphate (PPi) is released. PPi is converted in enzyme-catalyzed reactions to drive light ...
For example, DNA methylation modifies gene expression without altering the nucleotide sequence. A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent ...
DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...