A future challenge for synthetic chemists will be to craft novel bioorthogonal transformations for use in living organisms. Just as combinations of fluorescent proteins (such as CFP and YFP ...

Laboratory of Medicinal Chemical Biology, College of Pharmaceutic Sciences, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Suzhou Medical College, ...

An artificial intelligence model has created a new protein that researchers say would have taken 500 million years to evolve in nature — if nature were capable of producing such a thing.

fluorescent protein. Prior research has shown that synthesizing proteins can provide unique insights into the structure and function of natural proteins. To date, most such proteins are copies of ...

Fluorescent probes are molecules that absorb light of a specific wavelength and emit light of a different, typically longer, wavelength (a process known as fluorescence), and are used to study ...

It has been demonstrated that isocyanides can participate in biomolecule labeling through three strategies, including the two-component bioorthogonal reaction, multicomponent reaction, and metal ...

In modern life science research, fluorescence microscopy is a popular and powerful imaging technique. Yet, despite its overall success, the need for fluorescent labels limit its potential applications ...

HPLC grade solvents: water, methanol and acetonitrile were purchased from Fisher (Waltham, MA, United States). AHA and HPG were purchased from Click Chemistry Tools (Scottsdale, AZ, United States).