Introduction: The cholinergic anti-inflammatory pathway regulates immune responses through the alpha7 nicotinic acetylcholine receptor (α7nAChR), found in neurons, macrophages, and monocytes. α7nAChR ...

Department of Pharmaceutical Sciences, Medicinal Chemistry Section “Pietro Pratesi”, University of Milan, Via L. Mangiagalli 25, Milan 20133, Italy ...

According to the World Health Organization (WHO), over 22% of the global population smokes, with more than 9 million smoking-related deaths reported annually. Effective treatments to alleviate ...

In cultured hippocampal cells, POX applied at 0.3–3 μM in the presence of atropine to block muscarinic receptor overstimulation modified the frequency ... by noncompetitively and reversibly inhibiting ...

Visual hallucinations (VH) are commonly found in the course of synucleinopathies like Parkinson's disease and dementia with Lewy bodies. The incidence of VH in these conditions is so high that the ...

Due, in part, to the logical nature of the approach, combination therapy is already widely used in clinical practice. Although compounds with a combined cholinergic–glutamatergic action have ...

Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K. C. Chien and Peter Farrell Collaboratory, University of California San Diego, La Jolla, California 92093, United States ...

After the end of the four-week period of self-administration brain regions of the rats were assessed for alpha4beta2 nicotinic receptor binding. We found that male rats, like females, show higher ...

Touch receptors are a subtype of sensory neuron that are located in the skin and possess specialized endings that respond to mechanical stimulation. As part of the somatosensory system ...

Pattern recognition receptors (PRRs) are expressed by cells in the body in order to sense molecules that are associated with infection or tissue damage. They are important for activating the ...

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This study reports a model of 8 somatosensory areas of the rat cortex consisting of 4.2 million morphologically and electrically detailed neurons. The authors carry out simulation experiments aimed at ...