CAR-T therapies have had the most success so far in targeting B-cell CD19 antigens (which is why Kymriah and Yescarta exist). However, researchers are hunting down a range of other antigens in a ...

CAR-T therapies have had the most success so far in targeting B-cell CD19 antigens (which is why Kymriah and Yescarta exist). However, researchers are hunting down a range of other antigens in a broad ...

The plasticity of regulatory T cells (Treg) has been well demonstrated to be involved in exacerbating the progression of autoimmune diseases.14–17 Recent studies further showed that besides IL-10, B ...

we evaluated the specific cytotoxicity of anti-CD19 (HD37-dgRTA) and anti-CD22 (RFB4-dgRTA) ITs or their combination (Combotox) on patient-derived pre-B ALL cells maintained in vitro on a stromal ...

The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo. Methods Sequential ultrasound-guided ...

Mucosa-associated invariant T cells (MAIT ... Bacterial infection was defined as previously shown.5 B. To investigate the impact of faecal extracts on MAIT cells: stool samples were collected from 27 ...

More information: Kenji Oishi et al, MHC Class II‐Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy, Allergy (2025). DOI: 10.1111/all.16477 ...

In recent years, scientific studies have revealed that mucosal mast cells (MMCs), which are immune cells that arise from bone marrow, are excessively produced and play a key role in the severity ...

People who had lost their sense of smell after catching covid-19 partly regained it following the injection of blood cells called platelets into their noses, which could help to improve their ...

State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China ...

was found in high frequency and B cell lineage (CD10+, CD19+ and CD20+ cells) in low frequency in both nasal mucosa and polyps. The frequency of HLA-DR+ cells (most of which were activated T cells ...