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中山六院梁振兴团队通过肠癌类器官揭示结直肠腺瘤癌变关键机制
通过对6例CRC患者的正常肠粘膜、进展期腺瘤和癌变组织配对样本进行了RNA测序,从中筛选可能参与调控癌变过程的基因,结果显示参与谷氨酰胺代谢的关键酶GPT1在N-A-C过程中显著下调,具有高度一致性。在晚期CRC患者中GPT1表达较低,说明GPT1表 ...
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