Gene therapy involves the introduction of new genes into cells, to restore or add gene expression, for the purpose of treating disease. Most commonly a mutated gene is replaced with DNA encoding a ...

1 Department of Respiratory and Critical Care Medicine, Suzhou Hospital of Anhui Medical University, Suzhou, China 2 Department of Respiratory Medicine, Yiwu Chouzhou Hospital, Yiwu, China Objectives: ...

Key events in mesothelioma tumorigenesis encompass inactivation of the neurofibromatosis gene type 2 (NF2) and loss of INK4α/ARF, but other molecular mechanisms cannot be excluded. Inactivation ...

The company, which secured $200 million from investors in a private funding deal last week, learned Tuesday of a serious side effect experienced by one participant on a high dose of its Rett therapy.

Not all stressors have the same impact on health. Stress arising from threats to social safety is most likely to affect psychological, biological, and clinical outcomes. This is the conclusion ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Topics include targeted therapies; mechanisms of drug sensitivity and resistance; pharmacogenetics and pharmacogenomics; personalized medicine; immunotherapy; gene therapy; diagnostic biomarkers; ...

JMML subtypes are defined by specific RAS pathway mutations and display distinct gene, microRNA (miRNA) and long non-coding RNA expression profiles. Here we zoom in on circular RNAs (circRNAs), ...