The most dramatic phenotypes tend to be lost, as gross perturbations of immunity are likely to kill mice in a colony before the causal mutations achieve fixation by chance. Genetic differences are ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Antibiotics are powerful, fast-acting medications designed to eradicate bacterial infections. However, in recent years, their ...

Antibiotics are powerful, fast-acting medications designed to eradicate bacterial infections. However, in recent years, their dependability has waned as antibiotic resistant bacteria continues to ...

This model was generated using a gene-targeting strategy designed to enhance the production of human Aβ in the mouse brain without changing APP synthesis. Site-specific mutations were introduced into ...

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease ...

Scientists say identification of two epigenetically different states in mouse model opens door to "entirely new world of ...

Vimentin is a type III intermediate filament (IF) protein normally expressed in cells that develop into connective tissue, ...

A gene-edited mouse with two male parents has survived to adulthood, pushing new progress on stem cell research.

In two new papers, researchers from The Jackson Laboratory (JAX) report the successful use of two approaches -- gene therapy and bone marrow transplantation – to alleviate symptoms of multiple ...