Osteoclasts derive from a myeloid progenitor that gives rise to both the monocyte-macrophage lineage and the osteoclast lineage. A mononuclear pre-osteoclast exists that expresses both TRAP and CTR.

Using lineage ... macrophages (RPM), initially depleted by BCG exposure, are restored from both tissue-trained, self-renewing macrophages and from bone marrow-derived progenitors, fostering long ...

CAR-engineered macrophages were shown to actively migrate to tumor sites, could locally deliver cytokines and/or cytotoxic substances to antigen-specific environments when used as a drug delivery ...