Cornell researchers have identified a specific brain circuit that could lead to anxiety treatments without cognitive side ...

The findings point the way to treatment options targeting group 1 metabotropic glutamate receptors. This study is a major step toward the ultimate goal of treating fragile X syndrome (FXS), an ...

Scientists have pinpointed a brain circuit that, when activated, reduces anxiety without impairing memory. Using ...

In their study, published Jan. 28 in Neuron, the researchers examined the effects of experimental drug compounds that activate a type of brain-cell receptor called the metabotropic glutamate receptor ...

and it will also work on a metabotropic glutamate receptor subtype 7 negative allosteric modulator (NAM). Both are in preclinical development. Other companies working on PAMs include Cerevel ...