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PPM1B 或是胃癌诊疗新希望 —— 揭秘 TRIM25/PPM1B/CDK2 信号通路
PPM1B 在 GC 细胞中抑制增殖和迁移:研究人员构建了稳定过表达 PPM1B 的 AGS 和 MGC - 803 细胞系,结果发现,PPM1B 过表达显著抑制了这些细胞的增殖和迁移能力。相反,在 PPM1B 敲低和敲除的细胞中,细胞的增殖和迁移能力明显增强。这充分说明 PPM1B 在胃癌细胞中起 ...
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