为探究耐力运动诱导骨骼肌重塑的机制，深圳大学医学院等单位的研究人员开展相关研究，发现耐力运动抑制 Ythdf1，进而影响 Mstn 表达，促进骨骼肌生长和再生。该研究为防治衰老相关肌肉疾病提供新思路，值得科研人员一读。

the authors study the RNA methylation mechanism by the METTL3-METTL14 complex. This complex catalyzes the major epitranscriptome methylation mark of nuclear RNA, including mRNA and lncRNAs. They ...

The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression through various mechanisms. M6A methylation modification ...

YTHDF3 与 YTHDF1 的相互作用能够进一步提高翻译效率。METTL3 介导的 mRNA 环化也是通过与 eIF 相关亚基的相互作用实现的，METTL3 通过在 mRNA 的 5'UTR 和 3'UTR 引入 m6A 修饰，增强这些区域与翻译起始因子的接触，从而调节 mRNA 翻译。 m6A 在 mRNA 稳定性中的作用：多种 m6A ...

Objective Fat mass and obesity-associated protein (FTO), an eraser of N 6-methyadenosine (m6A), plays oncogenic roles in various cancers. However, its role in hepatocellular carcinoma (HCC) is unclear ...

3.2 The role of m6A methylation readers in liver cancer immunotherapy The immune microenvironment of HCC is composed of a complex network of tumor cells, immune cells, and stromal elements, all of ...

Shanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, ...

最近的证据表明，由METTL3-METTL14甲基转移酶复合物添加在RNA上的N 6 甲基腺苷（m 6 A）与组蛋白修饰有关，但m6A与DNA甲基化之间的联系仍然很少被探索。