Here, the authors identify that the TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis is essential for lysosome degradation, with FBXO3 functioning in lysosome integrity. Tao et al. show that epidermal growth ...

Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization.

These molecules, upregulated in cancer cells, are excreted through a surprising mechanism—lysosomal exocytosis. Researchers published their results in the Journal of Cell Biology on January 3 ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

Liquid Sunlight Alliance, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1 ...

Recent studies have identified dynamic membrane contact sites between mitochondria and lysosomes, independent of mitophagy and the lysosomal degradation of mitochondrial-derived vesicles (MDVs), ...

Abstract: In converter applications, the body diode SiC MOSFET is often repurposed as freewheeling diode to reduce cost and save space, it potentially leads the device to bipolar degradation. This ...

Abstract: Typically, deep network-based full-reference image quality assessment (FR-IQA) models compare deep features from reference and distorted images pairwise, overlooking correlations among ...

Background: The lysosome plays a vitally crucial role in tumor development and is a major participant in the cell death process, involving aberrant functional and structural changes. However, there ...

These molecules, upregulated in cancer cells, are excreted through a surprising mechanism—lysosomal exocytosis. Even more fascinating is the intricate relationship between lysosomal exocytosis ...