The team's work sheds light on the pivotal role of Lrrk2, a major risk gene for Parkinson's disease, in modulating macrophage functions and immune responses. Parkinson's disease (PD) is a ...

1Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways ...

Nevertheless, the genome-wide impact of SeMC on gene transcription remains to be elucidated. In this study, we employed an LPS-stimulated chicken HD11 macrophage-like cell model to identify the ...

To further elucidate the potential role of CD38 in regulation of NLRP3 inflammasome activation, we investigated whether apigenin attenuates NLRP3 inflammasome activation in human monocytes and ...