Nanomedicine. 2014;9(1):105-120. SNALP & its Application. SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid ...

LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.

To enhance mRNA distribution, Penn engineers have created an ideal “recipe” for ionizable lipids, essential lipid nanoparticles (LNPs) components, the molecules that underlie COVID-19 vaccines ...

However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...